The effects of Corylus Avellana on Serum Lipid Profile and Oxidative Stress in / Hyperlipidemic-diabetic Rats

  • Emel Serdaroğlu Kasikci Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University https://orcid.org/0000-0003-1566-5788
  • Ebru Emekli-Alturfan Department of Biochemistry, Faculty of Dentistry, Marmara University, Nişantaşı, İstanbul, Turkey https://orcid.org/0000-0003-2419-8587
  • Aysen Arat Department of Biochemistry, Faculty of Dentistry, Marmara University, Nişantaşı, İstanbul, Turkey https://orcid.org/0000-0002-8258-6118
Keywords: Hazelnut, hyperlipidemia, diabetes, lipids, glutathione, lipid peroxidation

Abstract

There is limited evidence suggesting that nuts improve plasma antioxidant potential. The aim of this study is to investigate the effects of the hazelnut consumption on serum lipids, atherogenic indexes (AI) and oxidant-antioxidant status in hyperlipidemicdiabetic rats. Wistar-albino rats of both sexes, weighing 200-250 g were used in this study. The group of animals used in this study, which consisted of 32 rats, were divided into four groups: Control, control + hazelnut, hyperlipidemic-diabetic, hyperlipidemicdiabetic + hazelnut. Each group was fed with control or hyperlipidemic diets with the same amount of hazelnut (0.63%) added for 12 weeks. Diabetes has been induced by streptozotocin injection in diabetic groups. Blood glucose, serum lipids, glutathione (GSH), lipid peroxidation (LPO), and AI and atherogenic index of plasma (AIP) have been evaluated after the experiment was over. In hyperlipidemic-diabetic group, AI, LPO, and serum lipid levels were found to have increased significantly, whereas high-density lipoprotein-cholesterol and GSH levels were found to have decreased significantly in comparison with the control group (p<0.01). Hyperglycemia was also seen to have increased
in this group. Impaired antioxidant-oxidant balance was noted to have improved, GSH increased while triglyceride decreased significantly (p<0.01). Hazelnut consumption also  increased blood GSH levels and AI levels in the control group. Consumption of hazelnut at this dose (0.63%) may improve oxidant-antioxidant balance in healthy and hyperlipidemic-diabetic status without increasing blood lipids.

Author Biographies

Emel Serdaroğlu Kasikci, Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University

Department of Molecular Biology and Genetics, Faculty of Engineering and Natural Sciences, Üsküdar University

Ebru Emekli-Alturfan, Department of Biochemistry, Faculty of Dentistry, Marmara University, Nişantaşı, İstanbul, Turkey

Department of Biochemistry, Faculty of Dentistry, Marmara University, Nişantaşı, İstanbul, Turkey

Aysen Arat, Department of Biochemistry, Faculty of Dentistry, Marmara University, Nişantaşı, İstanbul, Turkey

Department of Biochemistry, Faculty of Dentistry, Marmara University, Nişantaşı, İstanbul, Turkey

Serum glucose, lipids, and atherogenic indexes of the four groups
Published
2018-09-01
How to Cite
Serdaroğlu Kasikci, E., Emekli-Alturfan, E., & Arat, A. (2018). The effects of Corylus Avellana on Serum Lipid Profile and Oxidative Stress in / Hyperlipidemic-diabetic Rats. Disease and Molecular Medicine, 2(3), 45-50. https://doi.org/10.5455/dmm.20140803111541
Section
Original Article