Multiple Myeloma with Pleural Involvement after Pelvic Radiotherapy for Endometrial Carcinoma

  • Bülent Karagöz Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey
  • Alpaslan Özgün Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey
  • Oğuz Bilgi Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey
  • Zafer Küçükodacı Department of Pathology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey
  • Alev Akyol Erikci Department of Hematology, Emsey Hospital, Istanbul, Turkey
  • Özkan Sayan Department of Hematology, Medicana Hospital, Istanbul, Turkey
  • Emin Gökhan Kandemir Department of Medical Oncology, Memorial Hospital, Istanbul, Turkey
Keywords: Multiple myeloma, endometrial carcinoma

Abstract

Although ionizing radiation is strongest factor linked to multiple myeloma, increased myeloma risk has not been fully explained after pelvic radiation. Pleural involvement of MM is also rare. We present a MM case with pleural involvement as an unusual presentation diagnosed in fifth years of pelvic radiotherapy. A sixty-two-year-old woman with dyspnea and a mass in forehead was admitted to our clinic. Before five year, the patient had received pelvic external beam radiotherapy (RT) with dose of 40 Gy for endometrial adenocarcinoma. PET/CT scan detected FDG uptakes in frontal bone, right pleura, and sacrum. Lambda light chain type multiple myeloma with pleural involvement was diagnosed with histopathological examinations of frontal bone mass, bone marrow, and pleural fluid and with serum/urine electroforesis. The patient died in second course of VAD chemotherapy. Although relation between increased myeloma risk and pelvic radiation is not clear and pleural involvement is rare, multiple myeloma should be included to the differential diagnosis in patients received pelvic radiotherapy or in unexplained pleural effusion.

Author Biographies

Bülent Karagöz, Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey

Alpaslan Özgün, Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey

Oğuz Bilgi, Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey

Zafer Küçükodacı, Department of Pathology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey

Department of Pathology, Gulhane Military Medical Academy Haydarpasa Training Hospital, Istanbul, Turkey,

Alev Akyol Erikci, Department of Hematology, Emsey Hospital, Istanbul, Turkey

Department of Hematology, Emsey Hospital, Istanbul, Turkey

Özkan Sayan, Department of Hematology, Medicana Hospital, Istanbul, Turkey

Department of Hematology, Medicana Hospital, Istanbul, Turkey

Emin Gökhan Kandemir, Department of Medical Oncology, Memorial Hospital, Istanbul, Turkey

Department of Medical Oncology, Memorial Hospital, Istanbul, Turkey

Published
2013-12-31
How to Cite
Karagöz, B., Özgün, A., Bilgi, O., Küçükodacı, Z., Akyol Erikci, A., Sayan, Özkan, & Kandemir, E. (2013). Multiple Myeloma with Pleural Involvement after Pelvic Radiotherapy for Endometrial Carcinoma. Disease and Molecular Medicine, 1(4), 87-89. https://doi.org/10.5455/dmm.20140204105205
Section
Case Report

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