Leptospiral Immunoproteins as Potential Elements for Diagnostic Tests and Vaccine Development

  • Vedat Turhan GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey
  • Ergenekon Karagöz GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey
Keywords: Leptospirosis, Leptospira immunoglobulin, LipL32, LipL41

Abstract

Leptospirosis, which is caused by Leptospira spirochetes, is an acute, febrile, and systemic zoonotic infection that is particularly common in tropical regions around the world. The clinical manifestations range from an undifferentiated febrile illness to life threatening conditions. The majority (90%) of patients manifest a mild anicteric febrile illness, while minority of patients (%10) go on to develop a severe form that involves multiple organs and presents with high fever, jaundice, hemorrhagic diathesis, acute renal failure, hepatic necrosis, pulmonary involvement and cardiovascular collapse. In
this paper, we have summarized past and current findings about leptospiral antigens that are conserved among pathogenic leptospires. We have also mentioned leptospiral immunoproteins being utilized for diagnostic tests and vaccine studies.

Author Biographies

Vedat Turhan, GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey

GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey

Ergenekon Karagöz, GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey

GATA Haydarpasa Training Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey

Published
2013-09-01
How to Cite
Turhan, V., & Karagöz, E. (2013). Leptospiral Immunoproteins as Potential Elements for Diagnostic Tests and Vaccine Development. Disease and Molecular Medicine, 1(3), 61-67. https://doi.org/10.5455/dmm.20131101084543
Section
Review