Leptospiral Immunoproteins as Potential Elements for Diagnostic Tests and Vaccine Development
Leptospirosis, which is caused by Leptospira spirochetes, is an acute, febrile, and systemic zoonotic infection that is particularly common in tropical regions around the world. The clinical manifestations range from an undifferentiated febrile illness to life threatening conditions. The majority (90%) of patients manifest a mild anicteric febrile illness, while minority of patients (%10) go on to develop a severe form that involves multiple organs and presents with high fever, jaundice, hemorrhagic diathesis, acute renal failure, hepatic necrosis, pulmonary involvement and cardiovascular collapse. In
this paper, we have summarized past and current findings about leptospiral antigens that are conserved among pathogenic leptospires. We have also mentioned leptospiral immunoproteins being utilized for diagnostic tests and vaccine studies.