The Effect of Cisplatin-Etoposide Chemotherapy on Platelet Parameters in Lung Cancer Patients

  • Oguz Bilgi Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey
  • Bulent Karagoz Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey
  • Ahmet Alacacioglu Department of Medical Oncology, Ataturk Research and Training Hospital, Izmir, Turkey
  • Tolga Tuncel Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey
  • Alpaslan Ozgun Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey
  • Levent Emirzeoglu Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey
  • Emin Gokhan Kandemir Department of Medical Oncology, Memorial Hospital, Istanbul, Turkey
Keywords: platelet parameters, chemotherapy, mpv, thromboembolism, lung cancer

Abstract

The aim of this study was to investigate the effect of cisplatin etoposide chemotherapy on platelet indices in advanced stage lung cancer patients. Twenty advanced stage lung cancer patients who received cisplatin and etoposide chemotherapy and 35 healthy subjects were enrolled. The platelet indices  (platelet count, mean platelet volume (MPV), plateletcrit (Pct) and platelet distribution width (PDW)) and other blood count parameters were recorded in baseline, before second cycle and after sixth cycle of chemotherapy. In baseline analysis, white blood cell count, but not other blood parameters, were different in patient group compared with control group,. After six cycles of chemotherapy, PDW values were elevated than baseline analysis in lung cancer patients. Other platelet parameters were not changed after chemotherapy. This study showed that MPV, platelet count, or Pct don’t change after cisplatin-etoposide chemotherapy in lung cancer patients.

Author Biographies

Oguz Bilgi, Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Bulent Karagoz, Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Ahmet Alacacioglu, Department of Medical Oncology, Ataturk Research and Training Hospital, Izmir, Turkey

Department of Medical Oncology, Ataturk Research and Training Hospital, Izmir, Turkey

Tolga Tuncel, Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Alpaslan Ozgun, Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Levent Emirzeoglu, Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Department of Medical Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey

Emin Gokhan Kandemir, Department of Medical Oncology, Memorial Hospital, Istanbul, Turkey

Department of Medical Oncology, Memorial Hospital, Istanbul, Turkey

Published
2013-06-03
How to Cite
Bilgi, O., Karagoz, B., Alacacioglu, A., Tuncel, T., Ozgun, A., Emirzeoglu, L., & Kandemir, E. (2013). The Effect of Cisplatin-Etoposide Chemotherapy on Platelet Parameters in Lung Cancer Patients. Disease and Molecular Medicine, 1(2), 35-38. https://doi.org/10.5455/dmm.20130326023112
Section
Original Article

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